An ACE2 inhibitor
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MLN4760

Item No. 31327

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
CAS Number
305335-31-3
Synonyms
  • GL-1001
Molecular Formula
C19H23Cl2N3O4
Formula Weight
428.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly Soluble: 0.1-1 mg/mlMethanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
CC(C)C[C@@H](C(O)=O)N[C@H](C(O)=O)CC1=CN=CN1CC2=CC(Cl)=CC(Cl)=C2
InChi Code
InChI=1S/C19H23Cl2N3O4/c1-11(2)3-16(18(25)26)23-17(19(27)28)7-15-8-22-10-24(15)9-12-4-13(20)6-14(21)5-12/h4-6,8,10-11,16-17,23H,3,7,9H2,1-2H3,(H,25,26)(H,27,28)/t16-,17-/m0/s1
InChi Key
NTCCRGGIJNDEAB-IRXDYDNUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    MLN4760 is an inhibitor of angiotensin-converting enzyme 2 (ACE2; IC50 = 0.44 nM).1 It is selective for ACE2 over ACE and carboxypeptidase A (CPDA; IC50s = >100 and 27 µM, respectively). MLN4760 inhibits ACE2 hydrolysis of angiotensin I in vitro when used at a concentration of 1 µM.2 It also inhibits the protein-protein interaction between ACE2 and the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as the surface glycoprotein.3 In vivo, MLN4760 inhibits exogenous recombinant ACE2-induced prevention of angiotensin II-induced hypertension in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dales, N.A., Gould, A.E., Brown, J.A., et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J. Am. Chem. Soc. 124(40), 11852-11853 (2002).

    2. Ye, M., Wysocki, J., Gonzalez-Pacheco, F.R., et al. Murine recombinant ACE2: Effect on angiotensin II-dependent hypertension and distinctive ACE2 inhibitor characteristics on rodent and human ACE2. Hypertension 60(3), 730-740 (2012).

    3. Williams-Noonan, B.J., Todorova, N., Kulkarni, K., et al. An active site inhibitor induces conformational penalties for ACE2 recognition by the spike protein of SARS-CoV-2. J. Phys. Chem. B 125(10), 2533-2550 (2021).