A sesquiterpene alcohol with anticancer activity
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Isomer(s)
9002495(–)-α-Bisabolol
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(±)-α-Bisabolol

Item No. 31397

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,1R)-rel-α,4-dimethyl-α-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-methanol
CAS Number
515-69-5
Synonyms
  • DL-α-Bisabolol
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
SMILES
CC1=CC[C@@]([C@@](O)(C)CC/C=C(C)\C)([H])CC1
InChi Code
InChI=1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m0/s1
InChi Key
RGZSQWQPBWRIAQ-LSDHHAIUSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

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    50 g

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    100 g

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    Product Description

    (±)-α-Bisabolol is a sesquiterpene alcohol that has been found in M. chamomilla and has anticancer activity.1,2 It induces apoptosis in, and is cytotoxic to, T67 and U87 glioma cells when used at concentrations ranging from 3.5 to 10 µM.1 (±)-α-Bisabolol is also cytotoxic to primary acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) cells (IC50s = 14-65 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cavalieri, E., Mariotto, S., Fabrizi, C., et al. ɑ-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem. Biophys. Res. Commun. 315(3), 589-594 (2004).

    2. Cavalieri, E., Rigo, A., Bonifacio, M., et al. Pro-apoptotic activity of ɑ-bisabolol in preclinical models of primary human acute leukemia cells. J. Transl. Med. 9, 45 (2011).