An alkaloid with diverse biological activities
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

β-Carboline-1-carboxylic Acid

Item No. 31415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9H-pyrido[3,4-b]indole-1-carboxylic acid
CAS Number
26052-96-0
Synonyms
  • 1-Formic Acid-β-carboline
Molecular Formula
C12H8N2O2
Formula Weight
212.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)O
InChi Code
InChI=1S/C12H8N2O2/c15-12(16)11-10-8(5-6-13-11)7-3-1-2-4-9(7)14-10/h1-6,14H,(H,15,16)
InChi Key
VNPNEGORDFERGK-UHFFFAOYSA-N
Origin
Plant/Quassia amara
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $290

    Add

    5 mg

    $1,006

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities.1,2,3 It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells.2 β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 µg/ml, respectively).1 It also inhibits cAMP phosphodiesterase with an IC50 value of 96 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lai, Z.-Q., Liu, W.-H., Ip, S.-P., et al. Seven alkaloids from Picrasma quassioides and their cytotoxic activities. Chem. Nat. Compd. 50(5), 884–888 (2014).

    2. Cui, Y., Jiang, L., Yu, R., et al. β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. J. Ethnopharmacol. 243, 112096 (2019).

    3. Sung, Y.-I., Koike, K., Nikaido, T., et al. Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides BENNET, and inhibitory activities of related β-carboline alkaloids. Chem. Pharm. Bull. (Tokyo) 32(5), 1872-1877 (1984).