An inhibitor of EAAT1 and EAAT2
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TFB-TBOA (hydrate)

Item No. 31417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-3-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid, hydrate
Synonyms
  • CF3-Bza-TBOA
Molecular Formula
C19H17F3N2O6 • XH2O
Formula Weight
426.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mLDMSO: 30 mg/ml
SMILES
FC(F)(F)C1=CC=C(C(NC2=CC=CC(CO[C@H](C(O)=O)[C@H](N)C(O)=O)=C2)=O)C=C1.O
InChi Code
InChI=1S/C19H17F3N2O6.H2O/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27;/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29);1H2/t14-,15-;/m0./s1
InChi Key
BGQSOHVMCTUIIO-YYLIZZNMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $78

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    5 mg

    $293

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    10 mg

    $429

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    Product Description

    TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50 values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells.1 It is selective for EAAT1 and EAAT2 over EAAT3 (IC50 = 300 nM), as well as the choline, dopamine, GABA, norepinephrine, and serotonin transporters and a variety of neurotransmitter receptors at 10 µM. TFB-TBOA (10 µM) inhibits L-glutamate- and L-aspartate-induced currents in X. laevis oocytes. It induces convulsions in mice when administered at a dose of 0.2 µg/animal.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimamoto, K., Sakai, R., Takaoka, K., et al. Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Mol. Pharmacol. 65(4), 1008-1015 (2004).