A gp130 modulator
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RCGD 423

Item No. 31420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-bromophenyl)-4-phenyl-2-thiazolamine
CAS Number
108237-91-8
Molecular Formula
C15H11BrN2S
Formula Weight
331.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mM
SMILES
BrC(C=C1)=CC=C1NC2=NC(C3=CC=CC=C3)=CS2
InChi Code
InChI=1S/C15H11BrN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)
InChi Key
OUFYYVAASPLOAA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $124

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    10 mg

    $228

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    25 mg

    $376

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    Product Description

    RCGD 423 is a modulator of gp130.1 It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shkhyan, R., Van Handel, B., Bogdanov, J., et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann. Rheum. Dis. 77(5), 760-769 (2018).