A 5-HT3 receptor antagonist
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VUF 10166

Item No. 31423

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-3-(4-methyl-1-piperazinyl)-quinoxaline
CAS Number
155584-74-0
Molecular Formula
C13H15ClN4
Formula Weight
262.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
214, 259 nm
SMILES
ClC1=C(N2CCN(CC2)C)N=C3C=CC=CC3=N1
InChi Code
InChI=1S/C13H15ClN4/c1-17-6-8-18(9-7-17)13-12(14)15-10-4-2-3-5-11(10)16-13/h2-5H,6-9H2,1H3
InChi Key
FFXVTQDGTKEXHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $90

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    25 mg

    $176

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    50 mg

    $328

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    100 mg

    $523

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    Product Description

    VUF 10166 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3A (Ki = 0.04 nM).1 It is selective for 5-HT3A over 5-HT3AB receptors in radioligand binding assays (Ki = 2 nM), as well as α7 nicotinic acetylcholine receptors (nAChRs) at 100 µM. VUF 10166 also acts as a partial agonist at 5-HT3A receptors (EC50 = 5 µM in a patch-clamp assay using Xenopus oocytes expressing the human receptor).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thompson, A.J., Verheij, M.H.P., de Esch, I.J.P., et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J. Pharmacol. Exp. Ther. 341(2), 350-359 (2012).