For immunochemical detection of SARS-CoV/SARS-CoV-2 nucleocapsid protein
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SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Monoclonal Antibody (Clone 005)

Item No. 31428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • SARS-CoV/SARS-CoV-2 NP
  • SARS-CoV/SARS-CoV-2 Nucleoprotein
  • Severe Acute Respiratory Syndrome Coronavirus/Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein
Immunogen
Recombinant SARS-CoV nucleocapsid protein
Clone Designation
Monoclonal Mouse IgG1 Clone 005
Formulation (Request formulation change)
50 or 100 µl of protein A-purified monoclonal antibody
Storage Buffer
0.2 μm filtered PBS
Host
Mouse
Isotype
IgG
Applications
ELISA, WB (reducing conditions)
Species Reactivity
(+) SARS-CoV(+) SARS-CoV-2(-) MERS-CoV(-) HCoV-229E(-) HCoV-NL63(-) HCoV-HKU1(-) HCoV-OC43
UniProt Accession №
P59595
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    20 µl

    $66

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    100 µl

    $264

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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 nucleocapsid proteins are encoded by the N gene in SARS-CoV and SARS-CoV-2 RNA.1,2 SARS-CoV and SARS-CoV-2 are members of the Betacoronavirus genus of viruses that have approximately 79% sequence identity and share 27 T cell epitopes in common.3,4,5 The SARS-CoV-2 nucleocapsid protein has greater than 90% similarity to the SARS-CoV nucleocapsid protein and contains two unique B cell epitopes and two T cell epitopes that are structurally stable, non-allergenic, and induce production of IFN-γ.5,2 SARS-CoV and SARS-CoV-2 nucleocapsid proteins package the viral RNA into a helical ribonucleoprotein complex (RNP), which is a template for viral replication, and are integral for viral self-assembly and involved in regulation of the host cell cycle.6,2 SARS-CoV and SARS-CoV-2 are the causative agents of SARS and COVID-19, respectively, both of which are primarily respiratory illnesses characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.4,7,8 Cayman’s SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Monoclonal Antibody can be used for ELISA and Western blot (WB; reducing conditions) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kandeel, M., Ibrahim, A., Fayez, M., et al. From SARS and MERS CoVs to SARS-CoV-2: Moving toward more biased codon usage in viral structural and nonstructural genes. J. Med. Virol. 92(6), 660-666 (2020).

    2. Kwarteng, A., Asiedu, E., Sakyi, S.A., et al. Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques. Biomed. Pharmacother. 132, 110914 (2020).

    3. Lu, R., Zhao, X., Li, J., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet 395(10224), 565-574 (2020).

    4. Meo, S.A., Alhowikan, A.M., Al-Khlaiwi, T., et al. Novel coronavirus 2019-nCoV: Prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV. Eur. Rev. Med. Pharmacol. Sci. 24(4), 2012-2019 (2020).

    5. Ahmed, S.F., Quadeer, A.A., and McKay, M.R. Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies. Viruses 12(3), E254 (2020).

    6. Chang, C.-K., Hou, M.-H., Chang, C.-F., et al. The SARS coronavirus nucleocapsid protein – Forms and functions. Antiviral Res. 103, 39-50 (2014).

    7. Klok, F.A., Kruip, M.J.H.A., van der Meer, N.J.M., et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb. Res. 191, 145-147 (2020).

    8. Yang, F., Shi, S., Zhu, J., et al. Analysis of 92 deceased patients with COVID-19. J. Med. Virol. 92(11), 2511-2515 (2020).