An S1P1 and S1P5 receptor agonist
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GSK2018682

Item No. 31437

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-[5-chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid
CAS Number
1034688-30-6
Molecular Formula
C22H21ClN4O4
Formula Weight
440.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
225, 272, 302 nm
SMILES
O=C(CCCN1C=CC2=C(C3=NOC(C4=CN=C(OC(C)C)C(Cl)=C4)=N3)C=CC=C21)O
InChi Code
InChI=1S/C22H21ClN4O4/c1-13(2)30-22-17(23)11-14(12-24-22)21-25-20(26-31-21)16-5-3-6-18-15(16)8-10-27(18)9-4-7-19(28)29/h3,5-6,8,10-13H,4,7,9H2,1-2H3,(H,28,29)
InChi Key
NFIGDBFIDKDNIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $120

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    25 mg

    $278

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    50 mg

    $516

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    Product Description

    GSK2018682 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) and S1P5.1 It is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 receptors. GSK2018682 is efficacious in a mouse model of experimental autoimmune encephalomyelitis (EAE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, J., Gray, F., Henderson, A., et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin. Pharmacol. Drug Dev. 3(3), 170-178 (2014).