An inhibitor of the Nrf2-Keap1 protein-protein interaction
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ML-334

Item No. 31439

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2R)-2-[[(1S )-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-cyclohexanecarboxylic acid
CAS Number
1432500-66-7
Synonyms
  • LH601
Molecular Formula
C26H26N2O5
Formula Weight
446.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 40 mg/ml
SMILES
O=C([C@H]1[C@H](CCCC1)C(O)=O)N2CCC3=CC=CC=C3[C@H]2CN4C(C(C=CC=C5)=C5C4=O)=O
InChi Code
InChI=1S/C26H26N2O5/c29-23(20-11-5-6-12-21(20)26(32)33)27-14-13-16-7-1-2-8-17(16)22(27)15-28-24(30)18-9-3-4-10-19(18)25(28)31/h1-4,7-10,20-22H,5-6,11-15H2,(H,32,33)/t20-,21+,22-/m1/s1
InChi Key
LNENLABLFGGAFF-BHIFYINESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $293

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    Product Description

    ML-334 is an inhibitor of the protein-protein interaction between the transcription factor Nrf2 and its inhibitor Keap1.1 It binds to the Keap1 Kelch domain (IC50 = 1 µM) to induce dissociation and nuclear translocation of Nrf2 and activation of the antioxidant response element (ARE) in a cell-based assay (EC50 = 12 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, L., Magesh, S., Chen, L., et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg. Med. Chem. Lett. 23(10), 3039-3043 (2013).