A VDAC1 blocker
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VBIT-12

Item No. 31445

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[1-(1-naphthalenylmethyl)-4-(phenylamino)-4-piperidinyl]carbonyl]-glycine
CAS Number
2089227-65-4
Molecular Formula
C25H27N3O3
Formula Weight
417.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 15 mg/ml
λmax
224 nm
SMILES
O=C(CNC(C1(CCN(CC1)CC2=CC=CC3=C2C=CC=C3)NC4=CC=CC=C4)=O)O
InChi Code
InChI=1S/C25H27N3O3/c29-23(30)17-26-24(31)25(27-21-10-2-1-3-11-21)13-15-28(16-14-25)18-20-9-6-8-19-7-4-5-12-22(19)20/h1-12,27H,13-18H2,(H,26,31)(H,29,30)
InChi Key
JZDHWOWCHGYSGA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $132

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    10 mg

    $246

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    25 mg

    $479

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    Product Description

    VBIT-12 is a voltage-dependent anion channel 1 (VDAC1) inhibitor.1 It inhibits VDAC1 conductance in synthetic lipid membranes containing purified rat VDAC1 when used at concentrations ranging from 20 to 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., et al. VDAC1, mitochondrial dysfunction, and Alzheimer’s disease. Pharmacol. Res. 131, 87-101 (2018).