A prodrug form of CLP 257
Related Products
Active Metabolite(s)
30948CLP 257
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CLP 290

Item No. 31448

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl ester
CAS Number
1181083-81-7
Molecular Formula
C19H21FN4O3S
Formula Weight
404.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
λmax
243, 336 nm
SMILES
O=C(N1CCCC1)OC(C=C(C=C2)F)=C2/C=C3SC(N4CCCCN4)=NC\3=O
InChi Code
InChI=1S/C19H21FN4O3S/c20-14-6-5-13(15(12-14)27-19(26)23-8-3-4-9-23)11-16-17(25)22-18(28-16)24-10-2-1-7-21-24/h5-6,11-12,21H,1-4,7-10H2/b16-11-
InChi Key
DIXMMXNNKLCLOM-WJDWOHSUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $37

    Add

    5 mg

    $106

    Add

    10 mg

    $194

    Add

    25 mg

    $436

    Add
    Product Description

    CLP 290 is a carbamate prodrug form of the K+/Cl- cotransporter 2 (KCC2) activator CLP 257 (Item No. 30948).1 It increases the mechanical paw withdrawal threshold in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats when administered at a dose of 100 mg/kg.1,2 CLP 290 (35 mg/kg) also restores stepping ability, as well as increases body weight support and stride length, in a mouse model of paralysis induced by staggered spinal lesions.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gagnon, M., Bergeron, M.J., Lavertu, G., et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat. Med. 19(11), 1524-1528 (2013).

    2. Ferrini, F., Lorenzo, L.-E., Godin, A.G., et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci. Rep. 7(1), 3870 (2017).

    3. Chen, B., Li, Y., Yu, B., et al. Reactivation of dormant relay pathways in injured spinal cord by KCC2 manipulations. Cell 174(3), 521-535 (2018).