A pyrimidine analog and nitrosourea alkylating agent
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Nimustine (hydrochloride)

Item No. 31464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-urea, monohydrochloride
CAS Number
55661-38-6
Synonyms
  • ACNU
  • NSC-D 245382
Molecular Formula
C9H13ClN6O2 • HCl
Formula Weight
309.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 20 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
249 nm
SMILES
O=NN(CCCl)C(NCC1=CN=C(C)N=C1N)=O.Cl
InChi Code
InChI=1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H
InChi Key
KPMKNHGAPDCYLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $75

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    500 mg

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    1 g

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    5 g

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    Cayman Chemical
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    Product Description

    Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.1,2,3 It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.2 Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heal, J.M., Fox, P.L., and Schein, P.S. A structure-activity study of seven new water soluble nitrosoureas. Biochem. Pharmacol. 28(8), 1301-1306 (1978).

    2. Yoshida, J., Shibuya, N., Kobayashi, T., et al. Sensitivity to I-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chioroethyl)-3-nitrosourea hydrochloride (ACNU) of glioma cells in vivo and in vitro. Cancer 50(3), 410-418 (1982).

    3. Hasegawa, H., Shapiro, W.R., and Posner, J.B. Chemotherapy of experimental metastatic brain tumors in female Wistar rats. Cancer Res. 39(7 Pt 1), 2691-2697 (1979).