An internal standard for the quantification of faldaprevir
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Faldaprevir-d6

Item No. 31480

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2S)-N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-bromo-7-methoxy-2-[2-[(2-methyl-d3-1-oxopropyl)amino-3,3,3-d3]-4-thiazolyl]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethenyl-cyclopropanecarboxylic acid
CAS Number
2750534-88-2
Synonyms
  • BI-201335-d6
Molecular Formula
C40H43BrD6N6O9S
Formula Weight
875.9
Purity
≥99% deuterated forms (d1-d2)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): solubleDMSO: soluble
SMILES
O=C([C@H](C(C)(C)C)NC(OC1CCCC1)=O)N2C[C@H](OC3=C(C=CC(OC)=C4Br)C4=NC(C5=CSC(NC(C(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=N5)=C3)C[C@H]2C(N[C@@]6(C(O)=O)[C@H](C=C)C6)=O
InChi Code
InChI=1S/C40H49BrN6O9S/c1-8-21-17-40(21,36(51)52)46-34(49)27-15-23(18-47(27)35(50)32(39(4,5)6)44-38(53)56-22-11-9-10-12-22)55-29-16-25(26-19-57-37(43-26)45-33(48)20(2)3)42-31-24(29)13-14-28(54-7)30(31)41/h8,13-14,16,19-23,27,32H,1,9-12,15,17-18H2,2-7H3,(H,44,53)(H,46,49)(H,51,52)(H,43,45,48)/t21-,23-,27+,32-,40-/m1/s1/i2D3,3D3
InChi Key
LLGDPTDZOVKFDU-RNFXWOKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $401

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    Product Description

    Faldaprevir-d6 is intended for use as an internal standard for the quantification of faldaprevir by GC- or LC-MS. Faldaprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; IC50 = 3 nM for the HCV genotype 1b enzyme).1 It inhibits genotype 1a and 1b HCV RNA replication in replicon assays (EC50s = 6.5 and 3.1 nM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Llinàs-Brunet, M., Bailey, M.D., Goudreau, N., et al. Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335). J. Med. Chem. 53(17), 6466-6476 (2010).

    2. White, P.W., Llinàs-Brunet, M., Amad, M., et al. Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease. Antimicrob. Agents Chemother. 54(1), 4611-4618 (2010).