An endogenous kinin peptide agonist of bradykinin B2 and B1 receptors
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Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt)

Item No. 31481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine, trifluoroacetate salt
Synonyms
  • KRPPGFSPFR
  • Lys-BK
  • Lysine Bradykinin
Molecular Formula
C56H85N17O12 • XCF3COOH
Formula Weight
1188.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
NCCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@H](C(N2CCC[C@H]2C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CO)C(N4[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CCC4)=O)=O)=O)=O)=O)CCC1)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C56H85N17O12.C2HF3O2/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62;3-2(4,5)1(6)7/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64);(H,6,7)/t36-,37-,38-,39-,40-,41-,42-,43-,44-;/m0./s1
InChi Key
CJWNEIHQAHYJAN-KNJHKARMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $91

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    10 mg

    $160

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    25 mg

    $378

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    50 mg

    $662

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    Product Description

    Kallidin (380-389) is a short-lived kinin peptide involved in inflammation and pain.1 It binds to bradykinin B2 (IC50 = 0.63 nM) and B1 receptors (Ki = 3.23 nM) and acts as an agonist.1,2,3 It is formed in tissue, including the brain, via cleavage of low molecular weight kininogen (LMWK) by kallikrein serine proteases released in response to injury or inflammation and can be converted into bradykinin.1 Kallidin levels in interstitial muscle are increased in women with work-related trapezius myalgia.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dray, A. Kinins and their receptors in hyperalgesia. Can. J. Physiol. Pharmacol. 75(6), 704-712 (1997).

    2. Bastian, S., Loillier, B., Paquet, J.L., et al. Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterization. Br. J. Pharmacol. 122(2), 393-399 (1997).

    3. Hess, J.F., Borkowski, J.A., Macneil, T., et al. Differential pharmacology of cloned human and mouse B2 bradykinin receptors. Mol. Pharmacol. 45(1), 1-8 (1994).

    4. Gerdle, B., Hilgenfeldt, U., Larsson, B., et al. Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls - a microdialysis study of women. Pain 139(3), 578-587 (2008).