An internal standard for the quantification of tetranor-PGEM
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Unlabeled Version(s)
14840tetranor-PGEM
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tetranor-PGEM-d6

Item No. 314840

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2R,5R)-2-(2-carboxyethyl)-5-hydroxy-ε,3-dioxo-cyclopentaneoctanoic-α,α,β,β,γ,γ-d6 acid
CAS Number
1240398-16-6
Synonyms
  • tetranor-Prostaglandin E Metabolite-d6
Molecular Formula
C16H18D6O7
Formula Weight
334.4
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: Not StablePBS (pH 7.2): 1 mg/ml
SMILES
O=C1[C@H](CCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)[C@H](O)C1
InChi Code
InChI=1S/C16H24O7/c17-10(3-1-2-4-15(20)21)5-6-11-12(7-8-16(22)23)14(19)9-13(11)18/h11-13,18H,1-9H2,(H,20,21)(H,22,23)/t11-,12-,13-/m1/s1/i1D2,2D2,4D2
InChi Key
ZJAZCYLYLVCSNH-VFBFAAMGSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $299

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    50 µg

    $568

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    100 µg

    $1,076

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    Product Description

    tetranor-Prostaglandin E metabolite-d6 (tetranor-PGEM-d6) is intended for use as an internal standard for the quantification of tetranor-PGEM (Item No. 14840) by GC- or LC-MS. tetranor-PGEM is the major urinary metabolite of PGE2 (Item No. 14010).1 Urine levels of tetranor-PGEM are increased in patients with diabetic nephropathy.2 Increased urine levels are also associated with a higher risk of breast cancer in postmenopausal women with a body mass index (BMI) of less than 25 kg/m2.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neale, J.R., and Dean, B.J. Liquid chromatography-tandem mass spectrometric quantification of the dehydration product of tetranor PGE-M, the major urinary metabolite of prostaglandin E2 in human urine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 871(1), 72-77 (2008).

    2. Morita, Y., Kurano, M., Sakai, E., et al. Simultaneous analyses of urinary eicosanoids and related mediators identified tetranor-prostaglandin E metabolite as a novel biomarker of diabetic nephropathy. J. Lipid Res. 62, 100120 (2021).

    3. Cui, Y., Shu, X.O., Gao, Y.T., et al. Urinary prostaglandin E2 metabolite and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 23(12), 2866-2873 (2014).

    Product Citations

    Yang, J., Yamashita-Kanemaru, Y., Morris, B.I., et al. Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity. Nature (2025).

    Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS. Anal. Bioanal. Chem. 407(6), 1625-1639 (2015).