The calcium salt form of D-glucaric acid
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Calcium D-Glucarate (hydrate)

Item No. 31490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-glucaric acid calcium salt, monohydrate
CAS Number
5793-89-5
Synonyms
  • Calcium D-Saccharate
  • D-Glucaric Acid Calcium Salt
  • D-Saccharic Acid Calcium Salt
Molecular Formula
C6H8O8 • Ca [4H2O]
Formula Weight
320.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly solublePBS (pH 7.2): slightly soluble
SMILES
[O-]C([C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O)=O.[Ca+2].O.O.O.O
InChi Code
InChI=1S/C6H10O8.Ca.4H2O/c7-1(3(9)5(11)12)2(8)4(10)6(13)14;;;;;/h1-4,7-10H,(H,11,12)(H,13,14);;4*1H2/q;+2;;;;/p-2/t1-,2-,3-,4+;;;;;/m0...../s1
InChi Key
ZQWFSIZRQANUDA-WQMSYZFBSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Calcium D-glucarate is the calcium salt form of D-glucaric acid.1 D-Glucaric acid is an end product of D-glucuronic acid metabolism in mammals that has also been found in fruits and vegetables and has anticancer activity.2 It is produced by the oxidation of D-glucuronic acid and is a precursor in the biosynthesis of the β-glucuronidase inhibitor D-glucaro-1,4-lactone (D-saccharic acid 1,4-lactone; Item No. 18896) in vivo.1 Dietary administration of calcium D-glucarate (10% w/w) reduces tumor growth in a rat model of mammary tumorigenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA).3 Urinary D-glucaric acid levels have been used as a marker for xenobiotic-induced phase II metabolism in patients with rheumatoid arthritis or individuals exposed to environmental toxicants.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Walaszek, Z. Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Lett. 54(1-2), (1990).

    2. Zółtaszek, R., Hanausek, M., Kiliańska, Z., et al. The biological role of D-glucaric acid and its derivatives: potential use in medicine. Postepy. Hig. Med. Dosw. (Online) 62, 451-462 (2008).

    3. Walaszek, Z., Hanausek-Walaszek, M., Minton, J.P., et al. Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Carcinogenesis 7(9), 1463-1466 (1986).

    4. Addyman, R., Beyeler, C., Astbury, C., et al. Urinary glucaric acid excretion in rheumatoid arthritis: influence of disease activity and disease modifying drugs. Ann. Rheum. Dis. 55(7), 478-481 (1996).

    5. Idéo, G., Bellati, G., Bellohuono, A., et al. Urinary D-glucaric acid excretion in the Seveso area, polluted by tetrachloro-dibenzo-p-dioxin (TCDD): five years of experience. Environ. Health Perspect. 60, 151-157 (1976).