A triterpene saponin with diverse biological activities
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Isomer(s)
36025Gypsogenic Acid
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Quillaic Acid

Item No. 31512

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α,16α)-3,16-dihydroxy-23-oxo-olean-12-en-28-oic acid
CAS Number
631-01-6
Synonyms
  • Quillaja Sapogenin
Molecular Formula
C30H46O5
Formula Weight
486.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 1 mg/ml
SMILES
OC([C@]12[C@](CC(C)(CC2)C)([H])C3=CC[C@@]([C@@]4([C@@]([C@@](C)([C@H](CC4)O)C=O)([H])CC5)C)([H])[C@]5(C)[C@@]3(C[C@H]1O)C)=O
InChi Code
InChI=1S/C30H46O5/c1-25(2)13-14-30(24(34)35)19(15-25)18-7-8-21-26(3)11-10-22(32)27(4,17-31)20(26)9-12-28(21,5)29(18,6)16-23(30)33/h7,17,19-23,32-33H,8-16H2,1-6H3,(H,34,35)/t19-,20+,21+,22-,23+,26-,27-,28+,29+,30+/m0/s1
InChi Key
MQUFAARYGOUYEV-UAWZMHPWSA-N
Origin
Plant/Quillaja saponaria bark
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $349

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    50 mg

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    Product Description

    Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.1,2,3 It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively).1 Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).2 It reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guzmán, L., Villalón, K., Marchant, M.J., et al. In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents. Sci. Rep. 10(1), 10534 (2020).

    2. Arrau, S., Delporte, C., Cartagena, C., et al. Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice. J. Ethnaopharmacol. 133(1), 164-167 (2011).

    3. Rodríguez-Díaz, M., Delporte, C., Cartagena, C., et al. Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives. J. Pharm. Pharmacol. 63(5), 718-724 (2011).