An FH2 domain inhibitor
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SMIFH2

Item No. 31517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3-bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
CAS Number
340316-62-3
Molecular Formula
C15H9BrN2O3S
Formula Weight
377.2
Purity
≥98% (mixture of isomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
O=C1NC(N(C2=CC(Br)=CC=C2)C(/C1=C/C3=CC=CO3)=O)=S
InChi Code
InChI=1S/C15H9BrN2O3S/c16-9-3-1-4-10(7-9)18-14(20)12(13(19)17-15(18)22)8-11-5-2-6-21-11/h1-8H,(H,17,19,22)/b12-8+
InChi Key
MVFJHEQDISFYIS-XYOKQWHBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $135

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    Product Description

    SMIFH2 is an inhibitor of formin homology 2 (FH2) domains.1 It inhibits assembly of profilin-actin mediated by mouse formin mDia1(FH1FH2) with an IC50 value of approximately 15 μM. It also inhibits actin assembly mediated by FH1FH2 constructs of mDia2, C. elegans CYK-1, S. pombe Cdc12 or Fus1, or S. cerevisiae Bni1. SMIFH2 (25 μM) disassembles formin-dependent actin cables and contractile rings, but not Arp2/3-dependent actin patches, in fission yeast. It is cytotoxic to NIH3T3 fibroblasts (IC50 = 28 μM). SMIFH2 (10 μM) increases and decreases the percentage of NIH3T3 cells with thin and thick F-actin bundles, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rizvi, S.A., Neidt, E.M., Cui, J., et al. Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem. Biol. 16(11), 1158-1168 (2009).