A σ1 receptor ligand
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Biochemicals

Research Area

Cancer
Cell Migration & Metastasis
Neuroscience

4-IBP

Item No. 31518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-iodo-N-[1-(phenylmethyl)-4-piperidinyl]-benzamide
CAS Number
155798-08-6
Synonyms
  • NSC 667672
Molecular Formula
C19H21IN2O
Formula Weight
420.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 100µg/ml
λmax
252 nm
SMILES
O=C(C1=CC=C(C=C1)I)NC2CCN(CC2)CC3=CC=CC=C3
InChi Code
InChI=1S/C19H21IN2O/c20-17-8-6-16(7-9-17)19(23)21-18-10-12-22(13-11-18)14-15-4-2-1-3-5-15/h1-9,18H,10-14H2,(H,21,23)
InChi Key
HELCSESNNDZLFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $315

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    50 mg

    $589

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    Product Description

    4-IBP is a sigma-1 (σ1) receptor ligand (Ki = 1.7 nM).1,2 It is selective for σ1 over σ2 receptors (Ki = 25.2 nM). It inhibits the growth and migration of PC3 prostate cancer and A549 non-small cell lung cancer (NSCLC) cells, as well as the migration of C32 melanoma and U373 MG glioblastoma cells, when used at a concentration of 10 µM.1 4-IBP (2 mg/kg) increases survival in a U373 MG mouse xenograft model. It also increases firing of serotonergic neurons in the rat dorsal raphe nucleus when administered at a dose of 2 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mégalizzi, V., Mathieu, V., Mijatovic, T., et al. 4-IBP, a σ1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia 9(5), 358-369 (2007).

    2. Bermack, J.E., and Debonnel, G. Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands. Br. J. Pharmacol. 134(3), 691-699 (2001).