An OST inhibitor
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NGI 1

Item No. 31519

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide
CAS Number
790702-57-7
Synonyms
  • N-linked Glycosylation Inhibitor 1
Molecular Formula
C17H22N4O3S2
Formula Weight
394.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
287 nm
SMILES
O=C(C1=CC(S(N(C)C)(=O)=O)=CC=C1N2CCCC2)NC3=NC=C(C)S3
InChi Code
InChI=1S/C17H22N4O3S2/c1-12-11-18-17(25-12)19-16(22)14-10-13(26(23,24)20(2)3)6-7-15(14)21-8-4-5-9-21/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,18,19,22)
InChi Key
QPKGRLIYJGBKJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $86

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    25 mg

    $202

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    50 mg

    $376

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    Cayman Chemical
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    Product Description

    NGI 1 is an oligosaccharyltransferase (OST) inhibitor.1 It binds to and stabilizes the STT3B catalytic subunit of OST in a cellular thermal shift assay (CETSA) and inhibits N-linked glycosylation in a reporter assay using D54 ER-LucT cells (IC50 = 1.1 µM). NGI 1 (10 µM) reduces glycosylation and membrane localization of EGFR in H3255 lung adenocarcinoma cells and inhibits proliferation of PC-9 and A549 non-small cell lung cancer (NSCLC) cells. It inhibits dengue and Zika virus replication in HEK293 cells (EC50s = 0.85 and 2.2 µM, respectively).2 NGI 1 also reduces viral RNA in HEK293 cells infected with West Nile virus or yellow fever virus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lopez-Sambrooks, C., Shrimal, S., Khodier, C., et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat. Chem. Biol. 12(12), 1023-1030 (2016).

    2. Puschnik, A.S., Marceau, C.D., Ooi, Y.S., et al. A small-molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 21(11), 3032-3039 (2017).