An inhibitor of mutant EGFR and HER2 receptors
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Signaling
Growth Factor Receptor Signaling

Mobocertinib

Item No. 31522

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[[2-(dimethylamino)ethyl]methylamino]-2-methoxy-5-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-4-(1-methyl-1H -indol-3-yl)-5-pyrimidinecarboxylic acid, 1-methylethyl ester
CAS Number
1847461-43-1
Synonyms
  • AP32788
  • TAK-788
Molecular Formula
C32H39N7O4
Formula Weight
585.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/ml
SMILES
O=C(C1=C(C2=CN(C)C3=C2C=CC=C3)N=C(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)N=C1)OC(C)C
InChi Code
InChI=1S/C32H39N7O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(6)15-14-37(4)5)35-32-33-18-22(31(41)43-20(2)3)30(36-32)23-19-39(7)26-13-11-10-12-21(23)26/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36)
InChi Key
AZSRSNUQCUDCGG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $326

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    10 mg

    $554

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    25 mg

    $922

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    Cayman Chemical
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    Product Description

    Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors.1,2 It is selective for the HER2 exon 20 mutants HER2V659E, HER2G660D, HER2G309E, and HER2S310F over wild-type EGFR in Ba/F3 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chouitar, J., Vincent, S., Brake, R., et al. TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2. Abstracts S811, P2(13-32) (2018).

    2. Neal, J., Doebele, R., Riely, G., et al. Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLC. Abstracts S599, P1(13-44) (2018).