For the immunochemical detection of the H3K36M mutant
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Histone H3K36M Rabbit Monoclonal Antibody (Clone RM193)

Item No. 31547

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
A peptide corresponding to histone H3K36M mutant
Clone Designation
RM193
Formulation (Request formulation change)
100 or 400 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, IHC, WB
Cross Reactivity
(-) Wild-type histone H3
Species Reactivity
(+) Histone H3K36M mutant
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $412

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    400 µl

    $998

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    Product Description

    Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. Lysine 36 of histone 3 (H3K36) has functionally relevant acetylation and methylation states with roles in transcriptional activation. More than 90% of chondroblastomas contain a heterozygous mutation, replacing H3K36 with methionine 36 (H3K36M) in the histone H3 variant H3.3.1 This antibody reacts to the H3K36M mutant and does not detect wild-type histone H3.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fang, D., Gan, H., Lee, J.-H., et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science 352(6291), 1344-1348 (2016).