(+)-δ-Tocopherol

(+)-δ-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.^1,2 It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM.³ (+)-δ-Tocopherol (40 µM) decreases capillary formation of HMEC-1 blood endothelial cells.⁴ It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. (+)-δ-Tocopherol (10 µM) reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells.⁵ Dietary administration of (+)-δ-tocopherol (0.2%) reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model. [Matreya, LLC. Catalog No. 1790]

WARNING This product is not for human or veterinary use.

1. Brigelius-Flohé, R., and Traber, M.G. Vitamin E: Function and metabolism. The FASEB Journal 13(10), 1145-1155 (1999).

2. van Acker, F.A., Schouten, O., Haenen, G.R., et al. Flavonoids can replace α-tocopherol as an antioxidant. FEBS Lett. 473(2), 145-148 (2000).

3. Tafazoli, S., Wright, J.S., and O'Brien, P.J. Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem. Res. Toxicol. 18(10), 1567-1574 (2005).

4. Wells, S.R., Jennings, M.H., Rome, C., et al. α-, γ- and δ-tocopherols reduce inflammatory angiogenesis in human microvascular endothelial cells. J. Nutr. Biochem. 21(7), 589-597 (2010).

5. Bak, M.J., Gupta, S.D., Wahler, J., et al. Inhibitory effects of γ- and δ-tocopherols on estrogen-stimulated breast cancer in vitro and in vivo. Cancer Prev. Res. (Phila.) 10(3), 188-197 (2017).