A GABAB receptor agonist
Related Products
Isomer(s)
18600(±)-Baclofen
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(+)-Baclofen (hydrochloride)

Item No. 31595

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
βR-(aminomethyl)-4-chloro-benzenepropanoic acid, monohydrochloride
CAS Number
63701-55-3
Synonyms
  • (R)-Baclofen
Molecular Formula
C10H12ClNO2 • HCl
Formula Weight
250.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
220 nm
SMILES
OC(C[C@H](C1=CC=C(C=C1)Cl)CN)=O.Cl
InChi Code
InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
InChi Key
WMNUVYYLMCMHLU-QRPNPIFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    10 mg

    $40

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    25 mg

    $93

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    50 mg

    $152

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    Product Description

    (+)-Baclofen is a GABAB receptor agonist.1,2 In vivo, (+)-baclofen (1 and 3 mg/kg) increases latency to paw or tail withdrawal in the hot-plate test in mice.1 (+)-Baclofen (3 mg/kg) also reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thomas, D.A., Navarrete, I.M., Graham, B.A., et al. Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. Brain Res. 718(1-2), 129-137 (1996).

    2. Lorrai, I., Maccioni, P., Gessa, G.L., et al. R(+)-Baclofen, but not S(−)-baclofen, alters alcohol self-administration in alcohol-preferring rats. Front. Psychiatry 7, 68 (2016).