A GABAB receptor agonist
Related Products
Isomer(s)
18600(±)-Baclofen
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(+)-Baclofen (hydrochloride)

Item No. 31595

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
βR-(aminomethyl)-4-chloro-benzenepropanoic acid, monohydrochloride
CAS Number
63701-55-3
Synonyms
  • (R)-Baclofen
Molecular Formula
C10H12ClNO2 • HCl
Formula Weight
250.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
220 nm
SMILES
OC(C[C@H](C1=CC=C(C=C1)Cl)CN)=O.Cl
InChi Code
InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
InChi Key
WMNUVYYLMCMHLU-QRPNPIFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $40

    Add

    25 mg

    $93

    Add

    50 mg

    $152

    Add
    Product Description

    (+)-Baclofen is a GABAB receptor agonist.1,2 In vivo, (+)-baclofen (1 and 3 mg/kg) increases latency to paw or tail withdrawal in the hot-plate test in mice.1 (+)-Baclofen (3 mg/kg) also reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thomas, D.A., Navarrete, I.M., Graham, B.A., et al. Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. Brain Res. 718(1-2), 129-137 (1996).

    2. Lorrai, I., Maccioni, P., Gessa, G.L., et al. R(+)-Baclofen, but not S(−)-baclofen, alters alcohol self-administration in alcohol-preferring rats. Front. Psychiatry 7, 68 (2016).