IR 780

IR 780 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells.¹ It displays excitation/emission maxima of 780/799 nm, respectively.² IR 780 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein (bromosulfalein; Item No. 21058), and targeted to the mitochondria.¹ It has an additive effect on the increase in reactive oxygen species (ROS) production induced by sonodynamic therapy (SDT) in 4T1 breast cancer cells when used at a concentration of 16 µM.³ IR 780 (0.2 mg/kg, i.v.) preferentially accumulates in tumor tissue in MCF-7, HeLa, and MG-63 mouse xenograft models and in a syngeneic mouse model of chemically induced lung tumors, and its fluorescence is detectable for up to 20 days. It also has an additive effect on the SDT-induced reduction in tumor growth in an 4T1 murine mammary carcinoma model. IR 780 has been incorporated into heparin-folic acid-IR 780 nanoparticles for use in photothermal therapy.⁴

WARNING This product is not for human or veterinary use.

1. Zhang, C., Liu, T., Su, Y., et al. A near-infrared fluorescent heptamethine indocyanine dye with preferential tumor accumulation for in vivo imaging. Biomaterials 31(25), 6612-6617 (2010).

2. Baeten, J., Niedre, M., Dunham, J., et al. Development of fluorescent materials for diffuse fluorescence tomography standards and phantoms. Opt. Express 15(14), 8681-8694 (2007).

3. Li, Y., Zhou, Q., Deng, Z., et al. IR-780 dye as a sonosensitizer for sonodynamic therapy of breast tumor. Sci. Rep. 6, 25968 (2016).

4. Yue, C.H., Liu, P., Zheng, M., et al. IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy. Biomaterials 34(28), 6853-6861 (2013).