A fluorescent probe for in vivo tumor cell imaging
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Product Categories

Product Type

Biochemicals
Labeling & Detection
Fluorescent Probes

Research Area

Cancer

Application

Fluorescence

IR 783

Item No. 31633

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-[2-chloro-3-[2-[1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene]ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-(4-sulfobutyl)-3H-indolium, inner salt, monosodium salt
CAS Number
115970-66-6
Molecular Formula
C38H46ClN2O6S2 • Na
Formula Weight
749.0
Purity
≥95%
Emission
780 nm
Excitation
633 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
786 nm
SMILES
ClC1=C(CCC/C1=C\C=C2C(C)(C)C3=CC=CC=C3N\2CCCCS([O-])(=O)=O)/C=C/C4=[N+](CCCCS([O-])(=O)=O)C5=CC=CC=C5C4(C)C.[Na+]
InChi Code
InChI=1S/C38H47ClN2O6S2.Na/c1-37(2)30-16-5-7-18-32(30)40(24-9-11-26-48(42,43)44)34(37)22-20-28-14-13-15-29(36(28)39)21-23-35-38(3,4)31-17-6-8-19-33(31)41(35)25-10-12-27-49(45,46)47;/h5-8,16-23H,9-15,24-27H2,1-4H3,(H-,42,43,44,45,46,47);/q;+1/p-1
InChi Key
QQIQAVJARACLHE-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $40

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    100 mg

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    250 mg

    $96

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    Cayman Chemical
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    Product Description

    IR 783 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells.1,2 It displays excitation/emission maxima of 633/780 nm, respectively. IR 783 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein (bromosulfalein; Item No. 21058).1 In vivo, IR 783 (11.25 mg/kg) preferentially accumulates in tumor tissue in an ACHN kidney cancer mouse xenograft model.2 It has been conjugated to polyethylenimines for tumor-specific gene delivery.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yuan, J., Yi, X., Yan, F., et al. Near‑infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes. Mol. Med. Rep. 11(2), 821-828 (2015).

    2. Yang, X., Shao, C., Wang, R., et al. Optical imaging of kidney cancer with novel near-infrared heptamethine carbocyanine fluorescent dyes. J. Urol. 189(2), 702-710 (2013).

    3. De Los Reyes-Berbel, E., Salto-Gonzalez, R., Ortega-Muñoz, M., et al. PEI-NIR heptamethine cyanine nanotheranostics for tumor targeted gene delivery. Bioconjug. Chem. 29(8), 2561-2575 (2018).