A near-infrared heptamethine cyanine dye
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Product Categories

Product Type

Biochemicals
Labeling & Detection
Fluorescent Probes

Research Area

Cancer

Application

Fluorescence

MH 148

Item No. 31634

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(5-carboxypentyl)-2-[2-[3-[2-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]ethylidene]-2-chloro-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-3H-indolium, monobromide
CAS Number
172971-76-5
Synonyms
  • IR 808
Molecular Formula
C42H52ClN2O4 • Br
Formula Weight
764.2
Purity
≥95%
Emission
808 nm
Excitation
782 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
CC1(C2=CC=CC=C2N(/C1=C\C=C3C(Cl)=C(/C=C/C4=[N+](C5=CC=CC=C5C(C)4C)CCCCCC(O)=O)CCC\3)CCCCCC(O)=O)C.[Br-]
InChi Code
InChI=1S/C42H51ClN2O4.BrH/c1-41(2)32-18-9-11-20-34(32)44(28-13-5-7-22-38(46)47)36(41)26-24-30-16-15-17-31(40(30)43)25-27-37-42(3,4)33-19-10-12-21-35(33)45(37)29-14-6-8-23-39(48)49;/h9-12,18-21,24-27H,5-8,13-17,22-23,28-29H2,1-4H3,(H-,46,47,48,49);1H
InChi Key
SBSLCJXMLMGYFH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $60

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    100 mg

    $112

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    500 mg

    $497

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    Cayman Chemical
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    Product Description

    MH 148 is a near-infrared heptamethine cyanine dye.1 It displays excitation/emission maxima at 782 and 808 nm, respectively. MH 148 has been used for tumor imaging, conjugated to anticancer agents to improve solubility and tumor targeting, as well as incorporated into bimetallic nanoparticles for antitumor phototherapy in mice.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Peng, X., Cui, A., et al. Photostabilities of novel heptamethine 3H-indolenine cyanine dyes with different N-substituents. J. Photochem. Photobiol. A Chem. 181(1), 79-85 (2006).

    2. Raveendran, A., Surendran, S.P., Ser, J., et al. Heptamethine cyanine dye MHI-148-mediated drug delivery system to enhance the anticancer efficiency of paclitaxel. Int. J. Nanomedicine 16, 7169-7180 (2021).

    3. Jia, P., Ji, H., Liu, S., et al. Integration of IR-808 and thiol-capped Au-Bi bimetallic nanoparticles for NIR light mediated photothermal/photodynamic therapy and imaging. J. Mater. Chem. B. 9(1), 101-111 (2021).