An acridone alkaloid with antimalarial and anticancer activities
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Melicopine

Item No. 31636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dimethoxy-11-methyl-1,3-dioxolo[4,5-c]acridin-6(11H)-one
CAS Number
568-01-4
Molecular Formula
C17H15NO5
Formula Weight
313.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C1C2=C(N(C)C3=C4OCOC4=C(C(OC)=C13)OC)C=CC=C2
InChi Code
InChI=1S/C17H15NO5/c1-18-10-7-5-4-6-9(10)13(19)11-12(18)15-17(23-8-22-15)16(21-3)14(11)20-2/h4-7H,8H2,1-3H3
InChi Key
PEWWLIQAXYMMAN-UHFFFAOYSA-N
Origin
Plant/Melicope sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $183

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    5 mg

    $588

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    Cayman Chemical
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    Product Description

    Melicopine is an acridone alkaloid that has been found in Z. simulans and has antimalarial and anticancer activities.1 It is active against the chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum with IC50 values of 29.7 and 33.7 µg/ml, respectively. Melicopine is cytotoxic to PC-3M and LNCaP prostate cancer, but not non-cancerous HEK293, cells (IC50s = 47.9, 37.8, and >100 µg/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, C., Wan, J., Mei, Z., et al. Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans Hance. Pharmacogn. Mag. 10(37), 73-76 (2014).