A polyketide with immunosuppressant activity
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Remisporine B

Item No. 31669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5bS,7S,7aR,7bR,14bS)-7,7a,7b,8,14,14b-hexahydro-4,7,13-trihydroxy-2,11-dimethyl-5,14-dioxo-furo[2′,3′,4′:3,4]indeno[1,2-b:6,7-b′]bis[1]benzopyran-5b,7(5H)-dicarboxylic acid, dimethyl ester
CAS Number
571194-06-4
Molecular Formula
C30H24O12
Formula Weight
576.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
COC([C@]12[C@]3([H])[C@](C4=C(OC5=CC(C)=CC(O)=C5C4=O)C[C@@]3([H])[C@](O)(O2)C(OC)=O)([H])C6=C1C(C7=C(O)C=C(C)C=C7O6)=O)=O
InChi Code
InChI=1S/C30H24O12/c1-10-5-13(31)18-15(7-10)40-17-9-12-22-21(20(17)24(18)33)26-23(25(34)19-14(32)6-11(2)8-16(19)41-26)29(22,27(35)38-3)42-30(12,37)28(36)39-4/h5-8,12,21-22,31-32,37H,9H2,1-4H3/t12-,21-,22+,29+,30+/m1/s1
InChi Key
RRGJMIUFDPLICY-JJEZGDBSSA-N
Origin
Fungus/Remispora maritima
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $294

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    5 mg

    $1,025

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    Product Description

    Remisporine B is a polyketide and derivative of remisporine A that has been found in Penicillium and has immunosuppressant activity.1,2 It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 µg/ml, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, H., Chen, S., Liu, W., et al. Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2. Mar. Drugs 14(12), 217 (2016).

    2. Kong, F., and Carter, G.T. Remisporine B, a novel dimeric chromenone derived from spontaneous Diels–Alder reaction of remisporine A. Tetrahedron Lett. 44(15), 3119-3122 (2003).