A bacterial metabolite
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Conglobatin B

Item No. 31671

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3E,5R,7S,11E,15S-pentamethyl-8S,16S-bis(oxazol-5-ylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
Molecular Formula
C27H36N2O6
Formula Weight
484.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
C/C(C(O[C@@H](CC1=CN=CO1)[C@@H](C)C[C@@H](C)/C=C2\C)=O)=C\CC[C@H](C)[C@H](CC3=CN=CO3)OC2=O
InChi Code
InChI=1S/C27H36N2O6/c1-17-9-20(4)25(12-23-14-29-16-33-23)35-26(30)19(3)8-6-7-18(2)24(11-22-13-28-15-32-22)34-27(31)21(5)10-17/h8,10,13-18,20,24-25H,6-7,9,11-12H2,1-5H3/b19-8+,21-10+/t17-,18+,20+,24+,25+/m1/s1
InChi Key
ZSFACGJIQJJPDW-MWWGJRGRSA-N
Origin
Bacterium/Streptomyces conglobatus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $214

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    500 µg

    $745

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    Cayman Chemical
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    Product Description

    Conglobatin B is a bacterial metabolite that has been found in Streptomyces MST-91080 and has anticancer activity.1 It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 0.084 µg/ml) but not NFF human fibroblasts (IC50 = >100 µg/ml).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lacey, H.J., Booth, T.J., Vuong, D., et al. Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatin. J. Antibiot. (Tokyo) 73(11), 756-765 (2020).