A fungal metabolite
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Sartorypyrone D

Item No. 31676

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-(-)-4-hydroxy-3-[(2E,6E)-9-[(1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexyl]-3,7-dimethyl-2,6-nonadien-1-yl]-6-methyl-2H-pyran-2-one
CAS Number
1801167-48-5
Molecular Formula
C26H38O4
Formula Weight
414.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
CC(O1)=CC(O)=C(C/C=C(C)/CC/C=C(C)/CC[C@H]2C(C)(C)[C@@H](O)CCC2=C)C1=O
InChi Code
InChI=1S/C26H38O4/c1-17(10-13-21-23(27)16-20(4)30-25(21)29)8-7-9-18(2)11-14-22-19(3)12-15-24(28)26(22,5)6/h9-10,16,22,24,27-28H,3,7-8,11-15H2,1-2,4-6H3/b17-10+,18-9+/t22-,24+/m1/s1
InChi Key
YFZBONHCMBXFDD-JVRYRRRMSA-N
Origin
Fungus/Neosartorya sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Sartorypyrone D is a fungal metabolite that has been found in N. fischeri.1 It inhibits NADH fumarate reductase (NFRD; IC50 = 1.7 µM in A. suum mitochondria) and NADH oxidase (IC50 = 3 µM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and M. smegmatis in disc assays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaifuchi, S., Mori, M., Nonaka, K., et al. Sartorypyrone D: A new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897. J. Antibiot. (Tokyo) 68(6), 403-405 (2015).