An internal standard for the quantification of 17-phenyl trinor PGF2α ethyl amide
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Unlabeled Version(s)
1682017-phenyl trinor Prostaglandin F2α ethyl amide
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17-phenyl trinor Prostaglandin F2α ethyl amide-d4

Item No. 316820

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-amide-3,3,4,4-d4
Synonyms
  • Bimatoprost-d4
  • 15(S)-Bimatoprost-d4
  • 17-phenyl trinor PGF2α ethyl amide-d4
Molecular Formula
C25H33D4NO4
Formula Weight
419.6
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.3 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
InChi Code
InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1/i4D2,9D2
InChi Key
AQOKCDNYWBIDND-BJZNXRQDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $83

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    50 µg

    $158

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    100 µg

    $281

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    1 mg

    $1,980

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    Product Description

    17-phenyl trinor Prostaglandin F2α ethyl amide-d4 is intended for use as an internal standard for the quantification of 17-phenyl trinor prostaglandin F2α ethyl amide (Item No. 16820) by GC- or LC-MS. 17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series prostaglandin derivative and an agonist of FP receptors.1,2 It induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM).1 Ocular administration of 17-phenyl trinor PGF2α ethyl amide (0.03% w/v) reduces intraocular eye pressure (IOP) in normotensive dogs and ocular hypertensive monkeys.2 Formulations containing 17-phenyl trinor PGF2α ethyl amide have been used in the treatment of open angle glaucoma, ocular hypertension, and eyelash hypotrichosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharif, N.A., Williams, G.W., and Kelly, C.R. Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur. J. Pharmacol. 432(2-3), 211-213 (2001).

    2. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of bimatoprost (Lumigan™). Surv. Ophthalmol. 45(Suppl. 4), S337-S345 (2001).