An internal standard for the quantification of ropinirole
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Unlabeled Version(s)
23871Ropinirole (hydrochloride)
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Ropinirole-d7 (hydrochloride)

Item No. 31689

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-(propyl(propyl-d7)amino)ethyl)indolin-2-one, monohydrochloride
CAS Number
1261396-31-9
Synonyms
  • SKF 101468A-d7
Molecular Formula
C16H17D7N2O • HCl
Formula Weight
303.9
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): SolubleDMSO: Soluble
SMILES
O=C1NC2=CC=CC(CCN(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])CCC)=C2C1.Cl
InChi Code
InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H/i1D3,3D2,9D2;
InChi Key
XDXHAEQXIBQUEZ-DWPKPNNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

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    Product Description

    Ropinirole-d7 is intended for use as an internal standard for the quantification of ropinirole (Item No. 23871) by GC- or LC-MS. Ropinirole is a dopamine D2 receptor agonist that induces [35S]GTPγS binding in CHO cells expressing the human receptor (EC50 = 304 nM).1 It is selective for dopamine D2 over D1 receptors (Kis = 29 and >100,000 nM, respectively), as well as a panel of adrenergic, serotonin (5-HT), benzodiazepine, and GABA receptors (IC50s = >9,000 nM for all).2 Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson's disease induced by MPTP. Formulations containing ropinirole have been used in the treatment of Parkinson's disease motor dysfunction.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ghosh, B., Antonio, T., Reith, M.E.A., et al. Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson’s disease. J. Med. Chem. 53(5), 2114-2125 (2010).

    2. Eden, R.J., Costall, B., Domeney, A.M., et al. Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol. Biochem. Behav. 38(1), 147-154 (1991).