An internal standard for the quantification of rilmenidine
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Unlabeled Version(s)
32879Rilmenidine 16988Rilmenidine (hemifumarate)
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Rilmenidine-d4

Item No. 31691

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(dicyclopropylmethyl)-4,5-dihydro-4,5-d2-2-oxazol-4,5-d2-amine
CAS Number
85047-14-9
Molecular Formula
C10H12D4N2O
Formula Weight
184.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleMethanol: Soluble
SMILES
[2H]C(C([2H])([2H])O1)([2H])N=C1NC(C2CC2)C3CC3
InChi Code
InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)/i5D2,6D2
InChi Key
CQXADFVORZEARL-NZLXMSDQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $174

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    1 mg

    $329

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    Product Description

    Rilmenidine-d4 is intended for use as an internal standard for the quantification of rilmenidine (Item No. 16988) by GC- or LC-MS. Rilmenidine is an antihypertensive agent.1 It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.2 Rilmenidine (1 µM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.3 Formulations containing rilmenidine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gomez, R.E., Ernsbarger, P., Feinland, G., et al. Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. Eur. J. Pharmacol. 195(2), 181-191 (1991).

    2. Burke, S.L., Evans, R.G., and Head, G.A. Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertension. J. Hypertens. 29(5), 945-952 (2011).

    3. Williams, A., Sarkar, S., Cuddon, P., et al. Novel targets for Huntington’s disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 4(5), 295-305 (2008).