A byproduct in solid-phase peptide synthesis
Related Products
Enantiomer(s)
31699(R)-Aspartimide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

(S)-Aspartimide

Item No. 31700

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3S-amino-2,5-pyrrolidinedione
CAS Number
73537-92-5
Molecular Formula
C4H6N2O2
Formula Weight
114.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
N[C@@H]1C(NC(C1)=O)=O
InChi Code
InChI=1S/C4H6N2O2/c5-2-1-3(7)6-4(2)8/h2H,1,5H2,(H,6,7,8)/t2-/m0/s1
InChi Key
YDNMHDRXNOHCJH-REOHCLBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $229

    Add
    Product Description

    (S)-Aspartimide is a byproduct formed during solid-phase peptide synthesis (SPPS) of aspartic acid-containing peptides.1 Aspartimide is formed by cyclization of aspartic acid during Fmoc removal or peptide coupling.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruczyński, J., Lewandowska, B., Mucha, P., et al. Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acid. J. Pept. Sci. 14(3), 335-341 (2008).

    2. Neumann, K., Farnung, J., Baldauf, S., et al. Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups. Nat. Commun. 11(1), 982 (2020).