A synthetic glucocorticoid with anti-inflammatory and anti-allergic activities
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Mometasone

Item No. 31702

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β,16α)-9,21-dichloro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
CAS Number
105102-22-5
Synonyms
  • (+)-Mometasone
Molecular Formula
C22H28Cl2O4
Formula Weight
427.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble
SMILES
Cl[C@@]12[C@](CCC([C@@]2(C=C3)C)=CC3=O)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@](C(CCl)=O)(O)[C@@H](C4)C)C
InChi Code
InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChi Key
QLIIKPVHVRXHRI-CXSFZGCWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

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    Product Description

    Mometasone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic activities.1,2,3 In vivo, mometasone (3 mg/kg) reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury.1 Intranasal administration of mometasone (0.2 µg/animal) reduces nose-rubbing behavior, sneezing, and nasal mucosal levels of IL-4 in a mouse model of allergic rhinitis.2 Mometasone also reduces nasal mucosal epithelial destruction, fibrosis, and cilia loss in a rat model of rhinitis medicamentosa induced by oxymetazoline (Item No. 23826).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Mo, Y., Schlueter, C.F., et al. Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol. Appl. Pharmacol. 272(2), 408-413 (2013).

    2. Kim, D.H., Kim, B.-Y., Shin, J.-H., et al. Intranasal azelastine and mometasone exhibit a synergistic effect on a murine model of allergic rhinitis. Am. J. Otolaryngol. 38(2), 198-203 (2017).

    3. Cam, B., Sari, M., Midi, A., et al. Xylitol treats nasal mucosa in rhinitis medicamentosa: An experimental rat model study. Eur. Arch. Otorhinolaryngol. 6(11), 3123-3130 (2019).