A carotenoid with hepatoprotective activity
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Zeaxanthin Dipalmitate

Item No. 31703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,3′R)-β,β-carotene-3,3′-diol, 3,3′-dihexadecanoate
CAS Number
144-67-2
Synonyms
  • Physalien
Molecular Formula
C72H116O4
Formula Weight
1045.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: slightly soluble
SMILES
CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](OC(CCCCCCCCCCCCCCC)=O)CC2(C)C)=C(C)C[C@@H](OC(CCCCCCCCCCCCCCC)=O)C1
InChi Code
InChI=1S/C72H116O4/c1-13-15-17-19-21-23-25-27-29-31-33-35-37-49-69(73)75-65-55-63(7)67(71(9,10)57-65)53-51-61(5)47-41-45-59(3)43-39-40-44-60(4)46-42-48-62(6)52-54-68-64(8)56-66(58-72(68,11)12)76-70(74)50-38-36-34-32-30-28-26-24-22-20-18-16-14-2/h39-48,51-54,65-66H,13-38,49-50,55-58H2,1-12H3/b40-39+,45-41+,46-42+,53-51+,54-52+,59-43+,60-44+,61-47+,62-48+/t65-,66-/m1/s1
InChi Key
XACHQDDXHDTRLX-XLVVAOPESA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Zeaxanthin dipalmitate is a carotenoid that has been found in F. lycii and has hepatoprotective activity.1,2,3,4 It inhibits TGF-β-induced activation of hepatic stellate cells (IC50 = 186.34 µM).2 Zeaxanthin (25 mg/kg) reduces hepatic collagen deposition and levels of thiobarbituric acid reactive substances (TBARS), as well as the activity of serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP), in a rat model of hepatic fibrosis induced by bile duct ligation.3 It also decreases reactivated levels of hepatitis B virus (HBV) DNA and reduces hepatic steatosis, inflammation, and fibrosis in a model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient diet in HBV transgenic mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, Y., Ma, C., Li, Y., et al. Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii). Plant Foods Hum. Nutr. 60(4), 161-164 (2005).

    2. Zhang, G., Liu, Y., and Liu, P. Active components from sea buckthorn (Hippophae rhamnoides L.) regulate hepatic stellate cell activation and liver fibrogenesis. J. Agric. Food Chem. 66(46), 12257-12264 (2018).

    3. Kim, H.P., Lee, E.J., Kim, Y.C., et al. Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats. Biol. Pharm. Bull. 25(3), 390-392 (2002).

    4. Li, J.-J., Gao, H., Lv, Y., et al. Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice. J. Asian Nat. Prod. Res. 19(9), 910-923 (2017).