A purine nucleotide
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Guanosine 5'-diphosphate (sodium salt hydrate)

Item No. 31704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
guanosine, 5′-(trihydrogen diphosphate), disodium salt, hydrate
Synonyms
  • GDP
Molecular Formula
C10H13N5O11P2 • 2Na [XH2O]
Formula Weight
487.2
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
254 nm
SMILES
O=P(OP(O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@]([H])(N2C=NC3=C2NC(N)=NC3=O)O1.[Na+].[Na+].O
InChi Code
InChI=1S/C10H15N5O11P2.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1
InChi Key
SYNIMEQECSCTMW-CYCLDIHTSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $32

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    10 mg

    $48

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    25 mg

    $80

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    50 mg

    $141

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    Product Description

    Guanosine 5'-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5'-triphosphate (GTP; Item No. 16060).1 It has been used to study the conformations of GTPases.2 GDP (100 µM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Biochemistry. (2002).

    2. Vetter, I.R., and Wittinghofer, A. The guanine nucleotide-binding switch in three dimensions. Science 294(5545), 1299-1304 (2001).

    3. Yamada, M., Isomoto, S., Matsumoto, S., et al. Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel. J. Physiol. 499(Pt 3), 715-720 (1997).