An RSV fusion inhibitor
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JNJ-53718678

Item No. 31720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl]methyl]-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-imidazo[4,5-c]pyridin-2-one
CAS Number
1383450-81-4
Molecular Formula
C21H20ClF3N4O3S
Formula Weight
500.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
O=C1N(CC2=CC3=C(N2CCCS(C)(=O)=O)C=CC(Cl)=C3)C4=C(N1CC(F)(F)F)C=CN=C4O=C1N(CC2=CC3=C(N2CCCS(C)(=O)=O)C=CC(Cl)=C3)C4=C(N1CC(F)(F)F)C=CN=C4
InChi Code
InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3
InChi Key
GTQTUABHRCWVLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $72

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    25 mg

    $157

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    Cayman Chemical
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    Product Description

    JNJ-53718678 is an inhibitor of respiratory syncytial virus (RSV) fusion.1 JNJ-53718678 binds to and stabilizes the RSV fusion protein in its prefusion conformation.2 It reduces RSV replication in RSV-infected HeLa cells (IC50 = 0.5 nM) with a 50% cytotoxic concentration (CC50) of greater than 50 µM.1 JNJ-53718678 (4-100 mg/kg), administered prior to infection, reduces RSV viral titers in lavaged-lung tissue and viral RNA production in the lungs in a semi-permissive cotton rat model of RSV.2 JNJ-53718678 also reduces RSV viral titers in bronchoalveolar lavage fluid (BALF) in a fully replicative neonatal lamb model of RSV when administered at doses of 5 and 25 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vendeville, S., Tahri, A., Hu, L., et al. Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a potent and orally bioavailable fusion inhibitor of respiratory syncytial virus. J. Med. Chem. 63(15), 8046-8058 (2020).

    2. Roymans, D., Alnajjar, S.S., Battles, M.B., et al. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat. Commun. 8(1), 167 (2017).