An anticoagulant and vitamin K antagonist
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Phenprocoumon

Item No. 31730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
CAS Number
435-97-2
Synonyms
  • Ro 1-4849
Molecular Formula
C18H16O3
Formula Weight
280.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/mlEthanol: 5 mg/ml
λmax
276, 285, 309 nm
SMILES
O=C1OC2=C(C(O)=C1C(CC)C3=CC=CC=C3)C=CC=C2
InChi Code
InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3
InChi Key
DQDAYGNAKTZFIW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $131

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    25 mg

    $291

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    50 mg

    $435

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    Product Description

    Phenprocoumon is an anticoagulant and vitamin K antagonist.1,2 It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.1 Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.2 Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Jin, D.-Y., Stafford, D.W., et al. Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu. Blood 132(18), 1974-1984 (2018).

    2. Schmidt, W.E., and Jähnchen, E. Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in rats. J. Pharm. Pharmacol. 29(5), 266-271 (1977).