A σ receptor ligand
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

1,3-Di-o-tolylguanidine

Item No. 31736

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-bis(2-methylphenyl)-guanidine
CAS Number
97-39-2
Synonyms
  • NSC 132023
  • DTG
  • NSC 473
Molecular Formula
C15H17N3
Formula Weight
239.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
SMILES
CC1=CC=CC=C1NC(NC2=CC=CC=C2C)=N
InChi Code
InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
InChi Key
OPNUROKCUBTKLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 g

    $37

    Add

    100 g

    $69

    Add

    250 g

    $124

    Add

    500 g

    $194

    Add
    Product Description

    1,3-Di-o-tolylguanidine (DTG) is a sigma (σ) receptor ligand (Kis = 61 and 42 nM for σ1 and σ2 receptors, respectively).1 In vivo, DTG (10, 15, and 20 mg/kg, i.p.) increases latency to tail withdrawal in the tail flick test and induces hypothermia in mice.2 It decreases infarct size and increases the number of cortical and hippocampal NeuN-positive neurons in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kokornaczyk, A.K., Schepmann, D., Yamaguchi, J., et al. Thiazole-based σ1 receptor ligands: Diversity by late-stage C-H arylation of thiazoles, structure-affinity and selectivity relationships, and molecular interactions. ChemMedChem 12(13), 1070-1080 (2017).

    2. Kest, B., Mogil, J.S., Sternberg, W.F., et al. Antinociception following 1,3,-di-o-tolylguanidine, a selective σ receptor ligand. Pharmacol. Biochem. Behav. 50(4), 587-592 (1995).

    3. Ajmo, C.T., Jr., Vernon, D.O.L., Collier, L., et al. Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Curr. Neurovasc. Res. 3(2), 89-98 (2006).