A STING agonist
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SR 717 (lithium salt)

Item No. 31759

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-benzoic acid, monolithium salt
CAS Number
2375421-09-1
Molecular Formula
C15H8F2N5O3 • Li
Formula Weight
351.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
238, 290 nm
SMILES
O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]
InChi Code
InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1
InChi Key
ODSAJRWPLSVEHJ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

    $387

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    Cayman Chemical
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    Product Description

    SR 717 is an agonist of stimulator of interferon genes (STING; EC50 = 2.1 µM in a reporter assay).1 It is selective for STING over a panel of 468 kinases. SR 717 (30 mg/kg, i.p.) increases plasma IFN-β and IL-6 levels in mice. It also increases the intratumor frequency of CD69+CD8+ T cells, reduces tumor growth, and increases survival in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chin, E.N., Yu, C., Vartabedian, V.F., et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science 369(6506), 993-999 (2020).