An ENPP1 inhibitor
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ENPP1-IN-1

Item No. 31764

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-(7-methoxy-4-quinolinyl)phenyl]methyl]-sulfamide
CAS Number
2289728-58-9
Synonyms
  • N-[4-(7-Methoxyquinolin-4-yl)benzyl]sulfamide
  • MV 658
  • UUN28589
Molecular Formula
C17H17N3O3S
Formula Weight
343.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
234 nm
SMILES
O=S(N)(NCC1=CC=C(C2=C3C=CC(OC)=CC3=NC=C2)C=C1)=O
InChi Code
InChI=1S/C17H17N3O3S/c1-23-14-6-7-16-15(8-9-19-17(16)10-14)13-4-2-12(3-5-13)11-20-24(18,21)22/h2-10,20H,11H2,1H3,(H2,18,21,22)
InChi Key
UEJMNZDIQDULLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    ENPP1-IN-1 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1).1 It inhibits the hydrolysis of 2’3’-cGAMP (Item No. 19887) and the ATP analog p-nitrophenyl 5’-adenosine monophosphate (AMP-pNP; Kis = ≤100 and 100-1,000 nM, respectively, in enzyme assays). ENPP1-IN-1 enhances transcription of the gene encoding IFN-β in 2’3’-cGAMP-stimulated human foreskin fibroblast cells (HFF-1) in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gallatin, W.M., Odingo, J., Dietsch, G.N., et al. Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP-1) inhibitors and uses thereof. (2019).