An inducer of ROS production
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death

QD-394

Item No. 31769

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione
CAS Number
2132411-21-1
Molecular Formula
C19H19N5O2
Formula Weight
349.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.04 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): slightly soluble
λmax
271 nm
SMILES
O=C1C=C(C(C2=CN=CN=C12)=O)NC3=CC=C(N4CCN(CC4)C)C=C3
InChi Code
InChI=1S/C19H19N5O2/c1-23-6-8-24(9-7-23)14-4-2-13(3-5-14)22-16-10-17(25)18-15(19(16)26)11-20-12-21-18/h2-5,10-12,22H,6-9H2,1H3
InChi Key
INZGOHBCPALCGM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    QD-394 is an inducer of reactive oxygen species (ROS) production.1 It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 µM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 µM, respectively). QD-394 acts synergistically with napabucasin (Item No. 22255) to reduce colony formation in MIA PaCa-2 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, S., Sechi, M., Singh, P.K., et al. A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen species. J. Med. Chem. 63(17), 9838-9855 (2020).