A cyclodepsipeptide inhibitor of lipid droplet formation
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Beauveriolide I

Item No. 31774

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[L-alanyl-D-leucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl]
CAS Number
154491-55-1
Molecular Formula
C27H41N3O5
Formula Weight
487.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(C[C@@](OC([C@H](NC([C@@H](NC1=O)C)=O)CC(C)C)=O)([H])[C@@H](C)CCCC)N[C@H]1CC2=CC=CC=C2
InChi Code
InChI=1S/C27H41N3O5/c1-6-7-11-18(4)23-16-24(31)29-21(15-20-12-9-8-10-13-20)26(33)28-19(5)25(32)30-22(14-17(2)3)27(34)35-23/h8-10,12-13,17-19,21-23H,6-7,11,14-16H2,1-5H3,(H,28,33)(H,29,31)(H,30,32)/t18-,19-,21-,22+,23-/m0/s1
InChi Key
ZKSLFHXTWGEITF-JIORRVSTSA-N
Origin
Fungus/Beauveria bassiana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $193

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    1 mg

    $690

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    Product Description

    Beauveriolide I is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.1 It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.78 µM), in primary mouse peritoneal macrophages.1,2 Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 6 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Namatame, I., Tomoda, H., Si, S., et al. Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979. J. Antibiot. (Tokyo) 52(1), 1-6 (1999).

    2. Namatame, I., Tomoda, H., Ishibashi, S., et al. Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages. Proc. Natl. Acad. Sci. USA 101(3), 737-742 (2004).