An inhibitor of MMP-9 zymogen activation
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JNJ-0966

Item No. 31781

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(2-methoxyphenyl)amino]-4′-methyl[4,5′-bithiazol]-2′-yl]-acetamide
CAS Number
315705-75-0
Molecular Formula
C16H16N4O2S2
Formula Weight
360.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
λmax
261, 311 nm
SMILES
COC1=C(C=CC=C1)NC2=NC(C3=C(C)N=C(NC(C)=O)S3)=CS2
InChi Code
InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)
InChi Key
ZADCDCMLLGDCRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $116

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    10 mg

    $207

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    25 mg

    $469

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    Product Description

    JNJ-0966 is an inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation (IC50 = 440 nM).1 It is selective for MMP-9 over MMP-1, MMP-2, and MMP-3 zymogen activation at 10 μM and does not inhibit the catalytic activity of MMP-1, -2, -3, -9, or -14. It inhibits invasion of HT-1080 cells in a MatrigelTM assay (IC50 = 1 μM). JNJ-0966 (10 and 30 mg/kg, twice per day) reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scannevin, R.H., Alexander, R., Haarlander, T.M., et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. The Journal of Biological Chemisty 292(43), 17963-17974 (2017).