CAY10773

CAY10773 is a derivative of the ferroptosis inducer sorafenib (Item No. 10009644).¹ It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC₅₀s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC₅₀ = 23.19 µM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 µM) also induces autophagy with incubation times longer than eight hours.

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1. Chen, J.-N., Li, T., Cheng, L., et al. Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives. Eur. J. Med. Chem. 205, 112661 (2020).