Host: E. coli • AA: 18-193 • Tag: None • MW: 20 kDa
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FcγRIIIb/CD16b HNA-1b allotype (human, recombinant)

Item No. 31827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • FCG3
  • FCGR3B
  • FCGR3B* 02
  • FCR-10
  • FCRIIIb
Purity
≥95% estimated by SDS-PAGE
Source
Recombinant human FcγRIIIb expressed in E. coli
Amino Acids
18-193
MW
20 kDa
Formulation (Request formulation change)
Lyophilized from sterile 20 mM Tris (pH 7.4) with 50 mM sodium chloride
UniProt Accession №
O75015
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $361

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    1 mg

    $2,345

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    Cayman Chemical
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    Product Description

    Low affinity immunoglobulin γ Fc region receptor IIIb (FcγRIIIb) has roles in neutrophil adhesion, phagocytosis, and the respiratory burst.1 It is encoded by the FCGR3B gene in humans and is comprised of two immunoglobulin-like (Ig-like) extracellular domains that bind to IgG Fc and pentraxins, such as C-reactive protein. FcγRIIIb is synthesized as a precursor with a transmembrane domain and four-residue cytoplasmic domain that are cleaved in the endoplasmic reticulum, following which a glycosylphosphatidylinositol (GPI) anchor is added, which allows for membrane association of the mature protein.2,1 It can be expressed as three different allotypes known as human neutrophil antigens HNA-1a, HNA-1b, and HNA-1c, which are characterized by differential antibody binding affinities.1 FcγRIIIb is constitutively expressed in neutrophils and a subset of basophils and is shed from the cell surface as a soluble form via proteolytic cleavage during apoptosis or following neutrophil activation.1,3 Copy number variation of FCGR3B is associated with an increased risk of systemic lupus erythematosus (SLE) and primary Sjögren's syndrome.4 Cayman's FcγRIIIb/CD16b HNA-1b allotype (human, recombinant) protein consists of 176 amino acids and has a calculated molecular weight of 20 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niederer, H.A., Clatworthy, M.R., Willcocks, L.C., et al. FcγRIIB, FcγRIIIB, and systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1183(1), 69-88 (2010).

    2. Unkeless, J.C., Shen, Z., Lin, C.W., et al. Function of human FcγRIIA and FcγRIIIB. Semin. Immunol. 7(1), 37-44 (1995).

    3. Middelhoven, P.J., Van Buul, J.D., Hordijk, P.L., et al. Different proteolytic mechanisms involved in FcγRIIIb shedding from human neutrophils. Clin. Exp. Immunol. 125(1), 169-175 (2001).

    4. Mamtani, M., Anaya, J.-M., He, W., et al. Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases. Genes Immun. 11(2), 155-160 (2010).