Cystatin C (human, recombinant)

Cystatin C, also known as cystatin 3, is a member of the cystatin superfamily of cysteine protease inhibitors encoded by CST3 in humans.¹ It is a 120-amino acid peptide constitutively produced by all nucleated cells and, following signal peptide cleavage, is secreted in all tissues and body fluids.^1,2,3 Cystatin C is an inhibitor of endogenous cysteine proteases, including cathepsins B, H, and L, as well as lysosomal proteinases, that regulates extracellular matrix (ECM) production and degradation.¹ Due to the small size and basic pI of cystatin C, it is not freely filtered by the glomerulus and is reabsorbed by, and catabolized in, tubular epithelial cells, which facilitates its use as a biomarker of glomerular filtration rate (GFR). Serum and urine levels of cystatin C are increased in pediatric acute kidney injury patients.³ Cayman's Cystatin C (human, recombinant) protein can be used for enzyme activity assay applications. This protein consists of 131 amino acids and has a calculated molecular weight of 14.8 kDa.

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1. Newman, D.J. Cystatin C. Ann. Clin. Biochem. 39(2), 89-104 (2002).

2. Sarkar, P.D., Rajeshwari, G., and Shivaprakash, T.M. Cystatin C-A novel marker of glomerular filtration rate: A review. Indian J. Clin. Biochem. 20(1), 139-144 (2005).

3. Nakhjavan-Shahraki, B., Yousefifard, M., Ataei, N., et al. Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis. BMC Nephrol. 18(1), 120 (2017).