An internal standard for the quantification of fosinopril
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Unlabeled Version(s)
21899Fosinopril (sodium salt)
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Fosinopril-d7 (sodium salt)

Item No. 31917

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,4S)-4-cyclohexyl-1-(2-((R)-((S)-2-methyl-1-(propionyloxy)propoxy)(4-(phenyl-d5)butyl-4,4-d2)phosphoryl)acetyl)pyrrolidine-2-carboxylate, monosodium salt
CAS Number
1217819-83-4
Molecular Formula
C30H38D7NO7P • Na
Formula Weight
592.7
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): SolubleDMSO: SolubleWater: Soluble
SMILES
[O-]C([C@@H]1C[C@@](CN1C(C[P@](O[C@@H](C(C)C)OC(CC)=O)(CCCC([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)([H])C3CCCCC3)=O.[Na+]
InChi Code
InChI=1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24;/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35);/q;+1/p-1/t25-,26+,30+,39-;/m1./s1/i5D,7D,8D,13D,14D,15D2;
InChi Key
TVTJZMHAIQQZTL-ZPRIPZGZSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril (Item No. 21899) by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor fosinoprilat.1 Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure.2 Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DeForrest, J.M., Waldron, T.L., Harvey, C., et al. Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: In vitro and preclinical in vivo pharmacology. J. Cardiovasc. Pharmacol. 14(5), 730-736 (1989).

    2. McElmurray, J.H., III, Mukherjee, R., New, R.B., et al. Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: Comparative effects on left ventricular function and geometry. J. Pharmacol. Exp. Ther. 291(2), 799-811 (1999).